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The journal "Ateroskleroz"

2016 year, number 1

ELECTROPHYSIOLOGICAL SIGNS OF MYOCARDIAL DAMAGE ASSOCIATED WITH THE METABOLIC SYNDROME AND ITS COMPONENTS IN MEN WITH CORONARY ATHEROSCLEROSIS

N.A. Timoshenko1, Yu.I. Ragino1, O.V. Pushkina1, A.M. Chernyavskii2, S.Yu. Tcimbal2, M.I. Voevoda1
1Institute of Internal and Preventive Medicine SB RAMS, Russia, Novosibirsk, 630089, B. Bogatkova st., 175/1 h
2Research State of Circulation Pathology, Ministry of Public Health and Social Development, Russia, Novosibirsk, 630055, Rechkunovskaya st., 15 h
Keywords: электрофизиологические признаки, метаболические нарушение миокарда, коронарный атеросклероз, метаболический синдром, electrophysiological signs, myocardial metabolic disorders, coronary atherosclerosis, metabolic syndrome

Abstract

The aim of the study. Study of electrophysiological signs ofmyocardial metabolic disorders (MMD) and the search for their associations with metabolic syndrome (MS) in men with coronary atherosclerosis (CA). Materials and methods. The study included 123 men with stenotic CA, verified during coronary angiography (CAG), without acute coronary syndrome (ACS) and with stable angina functional class (FC) II-IV.Was spend ECG alone in 12 standard leads. We analyzed ECG signs of MMD (length of the interval QT, above the contour >5mm, ST segment depression below the contour >5mm non-ischemic type, T-wave changes, syndrome TV1> TV6, signs of left ventricular hypertrophy (LVH), arrhythmias and asequence). Evaluated components and markers MS: waist circumference (WC), body mass index (BMI), systolic and diastolic blood pressure (SBP, DBP) blood levels of total cholesterol (TC), cholesterol of lowand high-density lipoproteins (LDL-cholesterol, HDL-cholesterol), c-peptide, and glucose, tumor necrosis factor (TNF-alpha), interleukin 6 (IL-6). Results and discussion. It was found that men with a significant stenotic atherosclerosis of one or more branches of the coronary arteries has a high incidence of MS (69%), its features / components and nonspecific ECG signs of MMD. In addition, men with SC and MS or with the frequency component of the electrophysiological signs MMD ECG signs of LVHand syndrome TV1> TV6 higher by more than 1.5 times in comparison with the absence of MS. Conclusion. Results of the study reflect the impact of common metabolic disorders in the body of the emergence and development of not only the metabolic syndrome, and metabolic myocardial damage.