CRYSTAL STRUCTURE AND INSULIN-LIKE ACTIVITY OF A VANADIUM COMPLEX DERIVED FROM N'-(3,5-DICHLORO-2-HYDROXYBENZYLIDENE)-2-METHYLBENZOHYDRAZIDE
S. Han1, Y. Wang2
1Qiqihar University, Qiqihar, P. R. China
2Qiqihar Environmental Monitoring Central Station, Qiqihar, P. R. China
Keywords: hydrazone ligand, vanadium complex, crystal structure, insulin-like activity
Abstract
Vanadium complexes have been proved to possess an interesting insulin-like activity. The reaction of VO(acac)2 with N ¢-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide (H2L) in methanol affords a new mononuclear vanadium (V) complex [VOL(OMe)(MeOH)]. The structure of the complex is characterized by physicochemical methods and single crystal X-ray diffraction. The complex crystallizes as the monoclinic space group P 21/ n , with unit cell parameters a = 7.830(2) Å, b = 23.225(3) Å, c = 10.635(2) Å, b = 101.947(2)°, V == 1892.1(6) Å3, Z = 4, R 1 = 0.0404, wR 2 = 0.0953, S = 1.037. The X-ray analysis indicates that the V atom in the complex is in the octahedral coordination. The insulin-like activity of the complex is studied.
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