DIMEPHOSPHONE ANALOGUES. 3. MOLECULAR AND CRYSTAL STRUCTURE OF DIMEPHOSPHONE PYRIDINOYLHYDRАZONES EXHIBITING ANTIPHTHISIC ACTIVITY
E. V. Mironova, B. I. Buzykin, V. N. Nabiullin, I. A. Litvinov, V. F. Mironov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan
katy@iopc.ru
Keywords: dimephosphone pyridinoylhydrazones, dimephosphone nicotinoylhydrazone, dimephosphone iso-nicotinoylhydrazone, structure of acylhydrazones, geometrical isomers, amide conformers, X-ray crystallography, biological activity, toxicity, antiphthisic activity
Abstract
Molecular and crystal structures of dimephosphone nicotinoylhydrazone and dimephosphone iso-nicotinoylhydrazone exhibiting antiphthisic activity are studied. In contrast to aroylhydrazones of arylaldehydes, existing in the crystalline state as a mixture of two amide conformers, the studied hydrazones exist in the crystalline state in the single geometrical form EC=NEN—NZN—C(О).
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