Cytotoxic and Immunomodulating Properties of Silver and Platinum Nanocomposites
E. S. MOROZKIN1, I. A. ZAPOROZHCHENKO1, M. V. KHARKOVA1, A. V. CHEREPANOVA1, P. P. LAKTIONOV1, V. V. VLASOV1, B. G. SUKHOV2, G. F. PROZOROVA2, B. A. TROFIMOV2, M. V. KHVOSTOV3 and T. G. TOLSTIKOVA3
1Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Pr. Akademika Lavrentyeva 8, Novosibirsk 630090 (Russia)
morozkin@niboch.nsc.ru
2Favorsky Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Ul. Favorskogo 1, Irkutsk 664033 (Russia)
3Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Pr. Akademika Lavrentyeva 9, Novosibirsk 630090 (Russia)
Keywords: silver and platinum nanocomposites, primary and transformed cells, cytotoxicity, proinflammatory action
Pages: 147–154
Abstract
Results of the investigation of cytotoxic and immunomodulating action of silver nanocomposites Ag15 (7.8 % Ag) and Ag13 (5 % Ag) with poly(1-vinyl-1,2,4-triazole) and platinum with arabinogalactan on primary and transformed human cells in vitro are presented. It is demonstrated that nanocomposites of metals with biopolymers possess more clearly pronounced cytotoxic effect in comparison with metal nanoparticles and do not induce inflammation in cell lines under investigation. It is established that silver nanocomposite Ag15 possesses selective cytotoxicity with respect to the cells of cervical adenocarcinoma HeLa.
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