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The journal "Ateroskleroz"

2010 year, number 1

Study of antiatherogenic effects of simvaglyzin on rabbit's hypercholesterolemia model

YU.I. Ragino1, V.А. Vavilin2, N.F. Salakhutdinov3, S.I. Makarova2, Е.М. Stakhneva1, О.G. Safronova2
1 Institute of Internal Medicine, Siberian Division, Russian Academy of Medical Sciences
2 Institute of Molecular Biology and Biophysics, Siberian Division, Russian Academy of Medical Sciences
3 N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences
Keywords: simvaglyzin, simvastatin, hypercholesterolemia in rabbits, lipid profile, hepatic enzymes, antioxidant effect, endothelial dysfunction
Pages: 5-11

Abstract

In cholesterol-fed rabbits with hypercholesterolemia it was revealed that complex of simvastatin (SV) with glycyrrhizic acid (1-4), simvaglyzin (SVG) had reduced effect on total blood cholesterol (CH) in appropriated equiponderant doses of SV 40, 66,5 and 100 mkg/kg/per day that was equal to such effect of SV 200 mkg/kg/per day. The decrease in total blood CH was 39, 36, 47 и 38 %, respectively, compared to control group after 20 day of drugs administration. Myopathic effect of SVG, evaluated by the blood activity of creatine kinase, was 26, 24 and 29 % lower in stated 3 doses of SVG, respectively, compared to SV dose after 30 day of drugs administration. Also, SVG had antioxidative effect result from reducing of blood lipid peroxidation level on 27-41 % and normalizing endothelium function effect result from reducing of blood levels of von Willebrand factor and endothelin-1 on 26-58 % and 21-29 %, respectively, in appropriated equiponderant doses of SVG 66,6 and 40 mkg/kg/per day that was equal to such effect of SV 200 mkg/kg/per day.