MOLECULAR AND CRYSTAL STRUCTURE OF AN ETHANOL SOLVATE OF 6-O-METHYLERYTHROMYCIN A
Z.M. Jin, L.L. Ma, W.X. Wei, C.S. Lin, W.Z. Li
Keywords: Clarithromycin, ethanol solvate, supramolecular complex, crystal structure
Pages: 192-196
Abstract
6-O-Methylerythromycin A (clarithromycin) ethanol solvate, C38H69NO13⋅0.5(C2H5OH), crystallizes in orthorhombic space group P212121 with a = 8.8459(14), b = 14.616(2), c =
= 38.787(8) Å, V = 5014.9(15) Å3, Z = 4. The conformation of clarithromycin in the title compound is essentially the same as that in previously studied clarithromycin unsolvated crystal and its methanol solvate. However, the crystal structure of the title compound differs from the previously studied structures due to differences in hydrogen bonding which lead to different molecular packing arrangements. The lactone carbonyl oxygen atom is not involved in hydrogen bonding, which is consistent with IR data.
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