2-Hydroxyethylammonium Salts of Organylsulphanyl(sylphonyl)acetic Acids as Novel Pharmacologically Active Compounds
A. N. MIRSKOVA, R. G. MIRSKOV, S. N. ADAMOVICH and M. G. VORONKOV
Favorsky Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences,
Ul. Favorskogo 1, Irkutsk 664033 (Russia)
E-mail: mirskova@irioch.irk.ru
Keywords: organylsulphanyl(sulphonyl)acetic acids, 2-hydroxyethylammonium salts, synthesis, pharmacological activity
Pages: 429-439
Abstract
Preparative methods of the synthesis of organylsulphanyl(sulphonyl)acetic acids and their 2-hydroxyethylammonium salts developed by the authors are presented in this review. The latter salts represent a new class of pharmacologically active substances possessing antiaggregant, membrane-stabilizing, antioxidant, cytostatic, cardiotropic and hypocholesterolemic activity. Compounds with combined immunotropic and antitumour activity promising for the development of up-to-date remedies for treating immunodeficient, autoimmune, oncological and other diseases were found.
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