Antituberculosis Activity of Natural and Synthetic Compounds
L. N. Rogoza, N. F. Salakhutdinov, G. A. Tolstikov
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
rogoza@nioch.nsc.ru
Keywords: tuberculosis, tuberculosis with plural drug resistance, M. tuberculosis, antimycobacterial activity, antituberculosis activity, cytotoxicity, structure-property relationship
Pages: 343-375
Abstract
The review presents the most active natural and synthetic compounds those exhibit antimycobacterial activity providing the minimum inhibiting concentration (MIC) ≤ 5 μg/mL. For better understanding the structure-activity relationship, compounds with a high value of MIC are considered in some cases. The review covers the papers published within the range of 2001-first half of 2009. The information in the review is systematized with respect to chemical structures (the nitrogen-, oxygen-, sulphur-containing heterocyclic compounds, peptides, alkaloids, terpenoids and others.).
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