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Chemistry for Sustainable Development

2010 year, number 3

New Approaches to the Synthesis of Platinum Complexes Possessing Biological Activity

S. D. Kirik, A. K. Starkov, R. F. Mulagaleev
Keywords: antitumour preparations of platinum, cisplatin, X-ray structurals tudies, thermal analysis, solubility of salts
Pages: 261-267

Abstract

Results of investigations, carried out at the Institute of Chemistry and Chemcial Technology SB RAS, concerning the problem of search and development of methods to synthesize new complex compounds of platinum possessing biological activity are presented. Two series of compounds representing the analogues of cisplatin and oxplatin, respectively, are presented. New efficient synthesis procedures were developed, X-ray structural studies of the majority of compounds were performed. Thernal stability and solubility of compounds were established. The data obtained may serve as the basis for the industrial production and arrangement of the modern physicochemical monitoring of the composition and properties of these preparations.