Berberine: Chemistry and Biological Activity
I. V. Nechepurenko, N. F. Salakhutdinov, G. A. Tolstikov
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
niv@nioch.nsc.ru
Keywords: isoquinoline alkaloids, protoberberine alkaloids, berberine, dihydroberberine, lambertine, tetrahydroberberine, canadine, enamine, Berberis, Phellodendron, Hydrastis, antimicrobial activity, antibacterial activity, antifungal activity
Pages: 1-23
Abstract
In the review, materials are generalized concerning the chemistry and pharmacological properties of phytogenous alkaloid berberine available under the conditions of Russia. Methods for berberine isolation from plant raw material as well as the biological activity of berberine and its synthetic derivatives are considered. The reactions of berberine and its hydrogenated derivatives occurring both with the conservation of protoberberine skeleton and with its transformation are considered in detail.
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